2007-11-07T08:53:00.001-08:00

Azerbaijani Blog for Stem Cells

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The ability to renew themselves through mitotic cell division and can differentiate into a diverse range of specialized cell types

Photo Courtesy of learn.genetics.utah.edu

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Stem cell, Wikipedia

Stem Cell Therapy

The goal of any stem cell therapy is to repair a damaged tissue that can't heal itself.This might be accomplished by transplanting stem cells into the damaged area and directing them to grow new, healthy tissue.It may also be possible to coax stem cells already in the body to work overtime and produce new tissue.
Stem cell therapies involve more than simply transplanting cells into the body and waiting for them to go to work. A successful stem cell therapy requires an understanding of how stem cells work, combined with a reliable approach to ensuring that the stem cells perform the desired action in the body.

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Stem Cells in The Spotlight

New Scientist video round-up - November 16, 2007

Which primate has the fastest sperm?

Cellule staminali embrionali

Cellule staminali

Le cellule staminali del feto sono in grado di guarire la mamma

Cellule staminali del feto per guarire la mamma

Le cellule staminali del feto accorrono a riparare lesioni nel corpo della madre

Cellule staminali

Le cellule staminali embrionali

ICSI (Sperm Injection) for
Male Infertility

Intracytoplasmic sperm injection (ICSI)

Italia. "Cellule staminali: il futuro e' oggi", un convegno

Cellule staminali embrionali e adulte,come separare realtà e fantasia

Le cellule del feto che curano le madri

le cellule staminali umane

intervista allo staminalista Paolo De Coppi

Staminali: la ricerca continua

Cellule staminali umane autologhe e trasferimento di nucleo

CELLULE STAMINALI: QUELLA FONTE MERAVIGLIOSA

LE STAMINALI DEL FETO GUARISCONO LA MAMMA

Stem Cell Injection in China

Steam Cell Reasearch

Dagli embrioni chimera uomo-animale arriveranno le cellule staminali

Cellule staminali

The ability to create living tissues and organs in the lab
Professor Ali Khademhosseini

Photo courtesy of technologyreview.com

Photo courtesy of Mehrnews

This animation of a rotating Carbon nanotube shows
its 3D structure, Courtesy of Wikipedia

The ability to create living tissues and organs in the lab holds great promise for transplant medicine. But the traditional approach to tissue engineering--seeding the outside of a biodegradable scaffold with cells, without regard to their organization--hasn't gotten cells to behave the way they would in the body.

Courtesy of technologyreview.com

Ali Khademhosseini, assistant professor in medicine and health sciences and technology at Harvard Medical School, hopes to improve engineered tissues with an approach he likens to building with living Legos. As a first step toward creating a heart, he aligns cardiac muscle cells to form small, beating strings. He then embeds these strings in a supportive, gelatinous polymer to make building blocks that can be assembled into bundles resembling the sheets of muscle that make up the heart. He can also add other types of cells to the building blocks to provide support for the muscle. This aspect of the system is crucial, since natural tissues comprise cells of multiple types in structurally complex arrangements. By giving cells the same interconnections they have in the body, Khademhosseini hopes to create tissues that can be used to test new drugs and, eventually, to rebuild organs.

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Ali Khademhosseini, assistant professor in medicine and health sciences

معرفی پروفسور خادم حسینی

Functionalization of the biomaterials for tissue engineering scaffolds, Prof. Ali Khademhosseini, Harvard University, USA. His research: The development of micro- and nanoscale technologies to control cellular behavior with particular emphasis in developing microscale biomaterials and engineering systems for tissue engineering and drug delivery

پروفسور خادم حسینی

یکی از 5 فینالیست جایزه علمی BMW برای ارایه بهترین پایان نامه دکتری

Micro- and Nanoscale Technologies for 3D Tissue Engineering
Ali Khademhosseini, Ph.D., Assistant Professor, Harvard / MIT Division of Health Sciences and Technology, Brigham and Women’s Hospital
Tissues are highly organized in their geometry and architecture with respect to how cells are positioned relative to each other, as well as to the surrounding soluble factors and extracellular matrix molecules within a given microenvironment. Most existing methods of generating tissues in 3D have not been able to recapitulate the proper microstructure and function of 3D tissues in the body. The merger of microscale technologies and novel biomaterials is a potential approach to generate tissues that mimic the complexity of tissues in the body. The talk will describe the current state-of-the-art in the application of microscale technologies for 3D cell culture. Specifically, I will describe our work in controlling the 3D cellular microenvironment by encapsulation within engineered microscale biomaterials, by using microstructures to generate homogeneous microtissues, by controlling the spatial distribution of cells and molecules within hydrogels and by directly engineering the microvasculature into 3D structures.

Source:

Micro- and Nanoscale Technologies for 3D Tissue Engineering

یک محقق ایرانی

Ali Khademhosseini, Ph.D
Ali Khademhosseini is an Assistant Professor of Medicine and Health Sciences and Technology at Harvard-MIT's Division of Health Sciences and Technology and the Harvard Medical School. His research area includes the development of micro- and nanoscale technologies to control cellular behavior with particular emphasis in developing microscale biomaterials and engineering systems for tissue engineering and drug delivery. He received his Ph.D. in bioengineering from MIT, and MASc (2001) and BSc (1999) in chemical and biomedical engineering from University of Toronto.
http://www.tissueeng.net/lab/

MIT and University of Rochester researchers report important advances toward a therapeutic device

Ali Khademhosseini

The BioTECH Quarterly

Ali Khademhosseini is an Assistant Professor of Medicine and Health Sciences and Technology at Harvard-MIT's Division of Health Sciences and Technology and the Harvard Medical School. His research is based on developing micro- and nanoscale technologies to control cellular behavior with particular emphasis in developing microscale biomaterials and engineering systems for tissue engineering and drug delivery. He has published over 60 peer reviewedpapers, 75 abstracts and 14 issued or pending patents. He has received multiple awards including the Coulter Foundation Early Career (2006), Outstanding research mentor at MIT (2004), outstanding researcher in polymer science by OMNOVA / MIT (2005) and outstanding graduate student by Biomedical Engineering Society (2005). He received his Ph.D. in bioengineering from MIT (2005), and MASc (2001) and BASc (1999) degrees from University of Toronto both in chemical engineering.

Source:

Nanoquebec

Ali Khademhosseini, MASc, PhD, of the Harvard-MIT Biomedical Engineering Center at Brigham and Women’s Hospital, has been recognized by Technology Review magazine as one of the world’s top innovators under the age of 35. Khademhosseini was honored for his pioneering work in the development of novel tissue engineering and cell culture approaches. Selected from more than 300 nominees by a panel of expert judges and the editorial staff of Technology Review, the TR35 is an elite group of accomplished young innovators who exemplify the spirit of innovation in business, technology and the arts.
Source:

Pioneering work in the development of novel tissue engineering and cell culture approaches

Ali Khademhosseini, PhD, of BWH’s Center for Biomedical Engineering within the Department of Medicine, and students from The Harvard-MIT Division of Health, Sciences and Technology have developed a strategy for generating cross-linked hydrogel microstructures – defined as water-soluble, natural polymers – that can be controlled in shape and size for use in drug delivery and tissue engineering. These findings appear online and in the November 29, 2006 print issue of the Journal of the American Chemical Society.

Hydrogels are widely used in biomedical applications because they are flexible in function as a result of their significant water content. Until now, however, it has been difficult to make these variable microstructures from many types of hydrogels that crosslink by a chemical linker. Dr. Khademhosseini and his lab were able to create cross-linked hydrogel microstructures that can be controlled in shape and size by using a micromolding approach combined with the controlled release of the chelating agent.

By having the ability to manipulate cross-linked hydrogel microstructures, researchers can control how particles interact with the body (in drug delivery) and group together to create structures (in tissue engineering). Next steps for the researchers include using these microstructures to generate tissues.

The Coulter Foundation, the Center for Integration of Medicine and Innovation and Technology (CIMIT), and the Charles Stark Draper Laboratory funded this research.

Source:

Dr. Khademhosseini and his lab were able to create cross-linked hydrogel microstructures that can be controlled in shape and size by using a micromolding approach combined with the controlled release of the chelating agent

*Cultivation of human embryonic stem cells without the embryoid body step enhances osteogenesis in vitro.
*Fabrication of Multiphenotye cell arrays within reversibly sealed microfluidic channels for highthroughput analysis.
*“Fabrication of nanostructures of poly(ethylene glycol) and its application to protein and cell patterning”.

*Microencapsulation of cells within shape-controlled microgels as building blocks for tissueengineered organs.
*Microengineering the murine embryonic stem cell environment.
*Multi-phenotype cell arrays inside microfluidic channels.
*Odontogenic fate of stem cells

Tissue Imaging / Engineering Laboratory

CIMIT-backed researcher Ali Khademhosseini, PhD

"Magnetite-PLGA Microparticles for Oral Delivery of Insulin
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Author(s):
Jianjun Cheng, Christopher H. Yim, Benjamin A. Teply, Dennis Ho , Omid C. Farokhzad, Robert S. Langer

Magnetic responsive particles were designed for use in oral delivery of insulin. Magnetite nanoparticles (12 nm average size) were synthesized and co-encapsulated with insulin into poly(lactide-co-glycolide) (PLGA) microparticles (4.6  2.2 m average particle size) through the double-emulsion method. The spherical structures of resulting microparticles were well maintained at magnetite content 5 wt % or less. Mice were gavaged with 125I-insulin-magnetite-PLGA microparticles and a circumferential trans-abdominal magnetic field was applied forty minutes after administration to retard the transit of the microparticles in the intestinal tract. As control, mice were similarly dosed without the subsequent trans-abdominal magnetic field. Mice were sacrificed, and the intestinal radioactivity was 101% and 145% higher in treated mice versus the control at 6 h and 12 h, respectively. A single administration of 50 unit/kg Humulin R-magnetite-PLGA microparticles to the fasted mice resulted in 66% reduction of blood glucose level in the presence of external magnetic field at 12 h, compared to 27% reduction in the absence of magnetic field.

Knowledge Diffusion Network is a nonprofit organization

California Institute for Regenerative Medicine

The Khademhosseini Lab uses a multi-disciplinary approach, to develop microscale and nanoscale technologies with the ultimate goal of generating tissue-engineered organs and controlling cell behavior.

Education of Professor Khademhosseini

September 2001- Massachusetts Institute of Technology (MIT)
April 2005 Ph.D. in Bioengineering

PhD Thesis: “Nanoscale and microscale approaches for engineering the in vitro
cellular microenvironment”; Supervisor: Robert Langer

• Cumulative GPA: 5.0/5.0
September 1999- University of Toronto (U of T)
August 2001 M.A.Sc. in Chemical Engineering and Applied Chemistry in Collaboration with
Institute of Biomaterials and Biomedical Engineering (IBBME)

• Masters Thesis: “In vitro study of bone marrow derived progenitor cells in liverlike
microenvironments” ; Supervisor: Peter Zandstra and Michael Sefton
September 1995- University of Toronto
May 1999 B.A.Sc. in Chemical Engineering and Applied Chemistry and Collaborative
Program in Environmental Engineering (graduated with honors)
• Undergraduate Thesis: “A novel method to conformally coat mammalian cells
using magnetically driven beads”; Supervisor: Michael Sefton
• Cumulative Average, 1996-99: 88% (4th year average: 93% - rank: 2 of 73)

FUNDING:
Active:
2007-2009 National Institute of Health: R21
Microengineering the murine embryonic stem cell environment; Role: PI
2007-2010 ISN
Microencapsulation of cells within shape-controlled microgels as building blocks for tissue
engineered organs; Role: co-PI
2006-2007 CIMIT
Microencapsulation of cells within shape-controlled microgels as building blocks for tissue
engineered organs; Role: PI
2006-2008 Coulter Foundation
Microscale bottom-up cardiac tissue engineering; Role: PI
2006-2007 Draper Laboratory
Multi-phenotype cell arrays inside microfluidic channels; Role: co-I
2006 National Institute of Health: P20
Systems approach to bioengineering of the tooth; Role: co-PI
2005-2006 Draper Laboratory
High-Throughput Multi-Phenotype Cellular Arrays on Surfaces or within Microchannels
for Bioanalytical and Diagnostic Devices and Tissue Engineering; Role: co-I
2006-2008 Harvard Stem Cell Institute
Odontogenic fate of stem cells; Role: co-PI

Fujifilm Honeycomb Film : DigInfo

Bone Marrow Transplant - Saving Subash

Micro- and Nanoengineering of the Cell Microenvironment: Technologies and Applications

Direct Patterning of Protein- and Cell-Resistant Ploymeric Monolayers and Microstructures

Gene therapy is an introduction of genetic material into a cell for the production of a needed peptide or protein

Welcome to NNFC International Symposium on Nanotechnology 2007!

Engineered Cardiac Tissue Structure and Electrophysiology Directed by Nanopatterned Peg Hydrogels

Novel Inorganic-Organic Hydrogels for Tissue Engineered Vascular Grafts

learn about background of miniaturization technique, semi-conductor technique and nano-technique, and then learn physical laws and scaling technique for micro-/nano- scale

Prof. Kahp-Yang Suh School of Mechanical and Aerospace Engineering
Seoul National University

Professor Peter W. Zandstra:

Institute of Biomaterials and Biomedical Engineering
Department of Chemical Engineering and Applied Chemistry
University of Toronto

Stem cells have generated much excitement as a potential source of cells for cell-based therapeutics because of their ability to self-renew (divide while maintaining stem cell properties) and differentiate into functional cells (such as blood or heart cells). Consequently, stem cells may serve as a renewable source of cells for regenerative medicine. Despite this enormous potential, significant challenges remain in order to translate the demonstrated biological properties of stem cells into robust and efficacious therapies. We hypothesize that a quantitative systems-based approach, integrating both cell population dynamics and signaling networks involved in individual cell fate decisions, is required to accurately predict and control the generation of cells and tissues from stem cells. This presentation will review some of our efforts to guide the design of novel technologies for stem cell-based therapies, as well as discuss common themes and future challenges in the regulation of cell fate in multicellular systems.

Controlling size, shape and homogeneity of embryoid bodies using poly(ethylene glycol) microwells

Dr. Nebel

Walter Schottky Institute

Christoph E. Nebel

NEW DIAMOND and FRONTIER CARBON TECHNOLOGY

Semiconductor materials: From gemstone to semiconductor

Microscale technologies for tissue engineering and biology

Openwetware.org; Alik:Reprints, Khadem Hosseini

Tissue engineering / regenerative medicine is an emerging multidisciplinary field

Tissue Engineering is involved with using cells to form engineered products

Tissue Substitutes

Michael J. Embryo

CIRCULATION

Stem cell

Stem cells as a potential therapy for Diabetes, Parkinson's disease

Ben's Stem Cell News

Stem cells

Derivation of pluripotent epiblast stem cells from mammalian embryos

Stem Cell Research Progress Blog

NJ to vote on stem cell bond act

Science and Reason

Names of the following videos (left to right) are:
1)Stem Cell Research: Beyond Hype,
Real Hope
2)Stem Cell Research Documentary
3)Stem Cell Patient Interview
4)David Prentice on Amniotic Stem
Cell Research
5)Break-thru on Stem Cells with
StemEnhance
6)The StemTech Story
7) Zebrafish Research
8)How to Make Stem Cells
9)Stem Cell Research
10)Stem Cells - Once and for all

Understanding Embryonic
Stem Cells Part 1 of 6

John D. Gearhart, Ph.D. for funding
embryonic research

Names of the following videos (left to right) are:
1)Stem Cells and Human Cloning
2)Lifting the Ban: The Struggle
for Stem Cells (II)
3)Lifting the Ban: The Struggle
for Stem Cells (I)
4)Cell Sense
5)Embryo development video
6)Development of egg cells
7)ICSI
8)embriologia de mamiferos paulo
9)Embriologia cardiaca
10)Intracytoplasmic Sperm Injection
(ICSI) - Atlanta Georgia